Pixxoscan™ (Gadobutrol)

Pixxoscan is a high relaxivity macrocyclic gadolinium-based contrast agent providing effective MRI enhancement across a range of indications, expanding the GE HealthCare portfolio.1,2
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Features

Effective enhancement

High relaxivity, improving tissue visualisation in a low injection volume²⁻⁶

Macrocyclic structure

Macrocyclic chelate tightly binds
Gd³⁺ ion, providing high molecular stability¹

Convenient packaging options

A broad range tailored to
your procedural needs for
efficient patient care

Expertly manufactured

Reliably delivered with the quality assurance of GE HealthCare 

About Pixxoscan

As part of our comprehensive contrast media product portfolio, GE HealthCare is proud to offer Pixxoscan (gadobutrol), bioequivalent to that of Gadovist®. Pixxoscan is a macrocyclic, general-purpose GBCA used for a broad range of MRI procedures across a breadth of patient types.
Pixxoscan is available in a range of packaging options, has a well-established tolerability profile, and is manufactured in-house by GE HealthCare. Enhanced confidence in continuity of supply and in product availability is further supported by GE HealthCare’s vertically integrated Pixxoscan manufacturing process.
Efficacy

Pixxoscan has double the concentration of gadolinium at 1.0M

Gadobutrol is formulated at double the concentration of Gd3+ ions compared to other GBCAs, reducing the injection volume by half and producing a more focused bolus.2 Combined with a high r1 relaxivity, gadobutrol enhances detection, delineation, and characterisation in MRI.2,3,8-11
Download dosing chart
Image quality

Highly effective in both steady state and dynamic imaging2-6,12

The high relaxivity of Pixxoscan is an advantage when enhancing steady state imaging 3-6,12

Meanwhile, the narrower bolus of gadobutrol is designed to optimise visualisation during dynamic imaging, potentially offering advantages in certain clinical scenarios.2
Usage

Potential to improve diagnostic confidence across a broad range of indications11,13,14

Pixxoscan should be used when diagnostic information is essential and not available with unenhanced MRI.

Pixxoscan is indicated for diagnostic contrast enhancement in adult, adolescent, and young populations (including term newborns) for:14 

  • Body imaging, including breast and kidneys
  • CNS (cranial and spinal MRI and perfusion studies)
  • MR angiography (CE-MRA)
Pixxoscan is well tolerated across diverse patient populations.15,16

Hypersensitivity reactions: As with other intravenous contrast agents, Pixxoscan can be associated with anaphylactoid/hypersensitivity or other idiosyncratic reactions, characterized by cardiovascular, respiratory or cutaneous manifestations, and ranging to severe reactions including shock. In general, patients with cardiovascular disease are more susceptible to serious or even fatal outcomes of severe hypersensitivity reactions.
Packaging

Meeting procedural needs, with packaging that prioritises your workplace safety and efficiency

Pixxoscan offers a range of packaging:

  • Glass vials: 7.5 and 15mL
  • Bulk polymer bottles: 30ml
Our unique Polymer bottle packaging reduces hazard and downtime:

  • No more broken bottles, glass or ring-pull injuries17
It can also reduce costs and environmental impact:

Less storage space, lower disposal costs, reduced environmental impact17-19
Commitment

Pixxoscan is produced in Norway to the same exacting standards as our other contrast agents

Pixxoscan is manufactured in compliance with cGMP regulations and within predefined specifications set in accordance with ICH guidelines.

GE HealthCare continues to invest significantly in expanding our manufacturing capacity to ensure quality supply and distribution so that you can schedule procedures with confidence.20
References
1. Port M et al. Biometals 2008; 21(4): 469-908. 
2. Scott LJ. Clin Drug Investig 2018; 38(8): 773-84.
3. Szomolanyi P et al. Invest Radiol 2019; 54(9): 559-64.
4. Rohrer M et al. Invest Radiol 2005; 40(11): 715-24.
5. Shen Y et al. Invest Radiol 2015; 50(5): 330-8.
6. Noebauer-Huhmann IM et al. Invest Radiol 2010; 45(9): 554-8. 
7. GE HealthCare Data on File_GBCA_Use. 
8. Kramer JH et al. Invest Radiol 2013; 48(3): 121-8. 
9. Durmus T et al. Invest Radiol 2012; 47(3): 183-8. 
10. Hoelter P et al. Neuroradiology 2017; 59(12): 1233-9.
11. Gutierrez JE et al. Magn Reson Insights 2015; 8: 1-10.
12. Miller K et al. Imaging Med 2011; 3(1): 93–105.
13. Katakami N et al. Invest Radiol 2011; 46(7): 411-8.
14. Pixxoscan [Product Monograph]. Mississauga, ON: GE HealthCare; 2024.
15. Glutig K et al. Pediatr Radiol 2016; 46: 1317-23.
16. Prince MR et al. Eur Radiol. 2017; 27(1): 286-95.
17. Marshall G. Radiography 2008; 14: 128-34.
18. Gricar J et al. Radiol Manage 2007; SEP/OCT: 34-42.
19. Dhaliwal H et al. Int J Life Cycle Assess 2014; 19: 1965-73.
20. GE HealthCare Data on File, Investment November 2023.

cGMP: current good manufacturing practice
CNS: central nervous system
GBCA: gadolinium-based contrast agent
ICH: International Council for Harmonisation
MR: magnetic resonance
MRI: MR imaging

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